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KMID : 0043320010240030211
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Archives of Pharmacal Research
2001 Volume.24 No. 3 p.211 ~ p.213
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Cytotoxic Constituents of Psorale corylifolia
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Mar WC
Je KH/Seo EK
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Abstract
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A coumestan derivative, posoralidin(1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L.(Leguminosae) with the IC50 values of 0.3 a nd 0.4mcg/ml against the HT-29(colon) and MCF-7 (breast) human cancer cell lines, repectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A-541(lung)and HepG2(liver hepatoma) cancer lines.
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